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A deficiency in this vitamin can potentially result in irreversible neurological damage to the growing fetus due to impaired oxygen transport into cells

MTHFR mutation also can increase environmental risks for psychiatric disorders, such as MDD through interaction between genetic and epigenetic factors

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[] Additionally, single-cell sequencing and clinicopathological analysis of human coronary artery plaques revealed that inflammatory macrophages within the plaques exhibit decreased H3K9ac histone acetylation and impaired mitochondrial oxidative phosphorylation